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Associate Professor of Chemistry
B.S., POSTECH (Pohang University of Science and Technology); M.S., POSTECH (Pohang University of Science and Technology); Ph.D., POSTECH (Pohang University of Science and Technology); Postdoctoral research, University of California at Berkeley and Scripps Research Institute
Email:
Personal Homepage: http://www.nyu.edu/classes/ytchang/
Research Interests: Combinatorial and bioorganic chemistry, chemical biology, and functional genomics
Fellowships/Honors: Undergraduate Research Honor Award, Korean Research Foundation (1990)
Selected Works:
1. Finding Fluorescent Live Cell RNA Imaging Probes Using Combinatorial Approach, Li, Q.; Chang, Y. T.* Nature Protocols, in press (2007).
2. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling, Min, J. K.; Kim, Y. K.; Cipriani, P. G.; Kang, M.; Khersonsky, S. M.; Walsh, D. P.; Lee, J. Y.; Niessen, S.; Yates, J. R.; Gunsalus, K.; Piano, F.; Chang, Y. T.* Nat. Chem. Biol. 2007, 3, 55-59.
3. Colorimetric identification of carbohydrates by a pH indicator/ pH change inducer ensemble, Lee, J. W.; Lee, J. S.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2006, 45, 6485-6487.
4. Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors, Wang, S.; Chang, Y. T.* J. Am. Chem. Soc. 2006, 128, 10380-10381.
5. Chemical Genetics, Walsh, D. P.; Chang, Y. T.* Chem. Rev. 2006, 106, 2476-2530.
6. A high throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide, Kim, W.; Kim Y. K.; Min, J. K.; Kim, D. J.; Chang, Y. T.*; Hecht, M. H.* ACS Chem. Biol. 2006, 1, 461-469.
7. RNA-selective, live cell imaging probes for studying nuclear structure and function., Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T.* Chem. Biol. 2006, 13, 615-623.
8. Visual Artificial Tongue for Quantitative Metal Cation Analysis by an Off-the-Shelf Dye Array, Lee, J. W.; Lee, J. S.; Kang, M.; Su, A. I.; Chang, Y. T.* Chem. Eur. J. 2006, 12, 5691-5696.
9. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator, Snyder, J. R.; Hall, A.; Ni-Komatsu, L.; Khersonsky, S. M.; Chang, Y. T.; Orlow, S. J. Chem. Biol. 2005, 12, 477-484.
10. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of a-galactosylceramides, Yu, K. O. A.; Im, J. S.; Molano, A.; Dutronc, Y.; Illarionov, P. A.; Forestier, C.; Fujiwara, N.; Arias, I.; Miyake, S.; Yamamura, T.; Chang, Y. T.; Besra, G. S.; Porcelli, S. A. Proc. Nat. Acad. Sci. U. S. A. 2005, 102, 3383-3388.
11. Solid phase synthesis of styryl dye library and its application to amyloid sensors, Li, Q.; Lee, J. S.; Ha, C.; Park, C. B.; Yang G.; Gan, W. B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2004, 43, 6331-6335.
12. Facilitated forward chemical genetics using tagged triazine library and zebrafish embryo screening, Khersonsky, S. M; Jung, D. W.; Kang, T. W.; Walsh, D. P.; Moon, H. S.; Jo, H.; Jacobson, E. M.; Shetty, V.; Neubert, T. A.; Chang, Y. T.* J. Am. Chem. Soc. 2003, 125, 11804-11805.
13. Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold, Rosania, G. R.; Lee, J. W.; Ding, L.; Yoon, H. S.; Chang, Y. T.* J. Am. Chem. Soc. 2003,125, 1130-1131.
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