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Professor of Chemistry
B.S. (physical and polymer chemistry), SUNY; M.S. (physical and polymer chemistry) Syracuse; Ph.D. (physical and polymer chemistry) Syracuse; Postdoctoral research at Brooklyn Polytechnic Institute
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Research Interests: The overall objective is to understand mechanisms and consequences of damage in genomic DNA induced by environmental contaminants and other reactive chemical species present in the human body, employing well defined model systems
Affiliations: American Physical Society, American Association for the Advancement of Science, American Association for Cancer Research, American Society for Photobiology, Biophysical Society; Environmental Mutagen Society, American Chemical Society, Russian Academy of Sciences
Fellowships/Honors: President, American Society for Photobiology, 1994, 1995; Foreign Member, Russian Academy of Sciences, 1994; Fellow, American Physical Society, 1978
Selected Works:
Misiaszek, R., Crean, C., Geacintov, N.E., Shafirovich, V. Combination of Nitrogen Dioxide Radicals with 8-Oxo-7,8-dihydroguanine and Guanine Radicals in DNA: Oxidation and Nitration End-Products. J. Am. Chem. Soc. 127(7):2191-200 (2005).
Hsu GW, Huang X, Luneva NP, GeacintovNE, Beese LS. Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. J Biol Chem. 280, 3764-70 (2005).
Zhang, N., Lin, C., Huang, X., Kolbanovskiy, A. , Hingerty, B.E., Amin, S., Broyde, S., Geacintov, N.E., and Patel, D.J. Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement. J. Mol. Biol. 346, 951–965 (2005). Cover
Misiaszek, R., Uvaydov, Y., Crean, C., Geacintov, N.E., Shafirovich, V. Combination Reactions of Superoxide with 8-Oxo-7,8-dihydroguanine Radicals in DNA. J. Biol. Chem. 280, 6293–6300 (2005).
Jia L, Shafirovich V, Shapiro R,GeacintovNE, Broyde S. Spiroiminodihydantoin lesions derived from Guanine oxidation: structures, energetics, and functional implications. Biochemistry 26, 6043-51 (2005).
Wang L, Wu M, Yan SF, Patel DJ, Geacintov NE, Broyde S. Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations. Chem Res Toxicol. 18, 441-56 (2005).
Kolbanovskiy A, Kuzmin V, Shastry A, Kolbanovskaya M, Chen D, Chang M, Bolton JL, Geacintov NE. Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin. Chem Res Toxicol. 18, 1737-47 (2005).
Crean C, Geacintov NE, Shafirovich V. Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: insight from oxygen-18 labeling experiments.
Angew Chem Int Ed Engl. 44: 5057-60 (2005).
Zhao, B., Wang, J., Geacintov, N.E., and Wang, Z. Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells. Nucleic Acids Res. 13, 417-25 (2006).
Rechkoblit O, Malinina L, Cheng Y, Kuryavyi V, Broyde S, Geacintov NE, Patel DJ. Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion. PLoS Biol. 4(1):e11 (2006).
Royzen M, Durandin A, Young VG Jr, Geacintov NE, Canary JW. A sensitive probe for the detection of Zn(II) by time-resolved fluorescence. J Am Chem Soc. 128:3854-5 (2006).
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