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Margaret and Herman Sokol Professor of Chemistry;
B.S. University of Chicago; Ph.D. University of Pittsburgh; Postdoctoral research at Columbia University and MIT
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Research Interests: DNA Nanotechnology, Macromolecular Design and Topology, Biophysical Chemistry of Recombinational Intermediates, DNA-Based Computation, and Crystallography
Affiliations: American Crystallographic Association
American Association for the Advancement of Science
Biophysical Society
New York Academy of Sciences
American Chemical Society
Sigma Xi
American Society for Biochemistry and Molecular Biology
Materials Research Society
Pittsburgh Diffraction Society
Fellowships/Honors: Damon Runyon Fellow (1972-3),
NIH Postdoctoral Fellow (1973-1976),
Sidhu Award for RNA crystallography (1974),
Basil O'Connor Fellow (1978-1981),
NIH Research Career Development Award (1982-1987),
Feynman Prize in Nanotechnology for the construction of DNA polyhedra (1995),
Discover award in Emerging Technologies for DNA tinkertoys (1997),
Honorary Distinguished Prof., Univ. Peruana Cayetano Heredia(1998-),
Elected AAAS Fellow(1998),
Margaret and Herman Sokol Award in the Sciences, for founding DNA nanotechnology (1999),
Margaret and Herman Sokol Chair in Chemistry, New York University (2001-),
Tulip Award in DNA-Based Computation (2004),
Elected Fellow of Royal Society of Chemistry (2005),
NIH MERIT Award (2005), Nanotech Briefs Nano50 Innovator Award for DNA nanotechnology (2005),
World Technology Network Biotechnology Award (2005),
Festschrift Volume, Nanotechnology: Science and Computation, (J.Chen, N.Jonoska, G.Rozenberg, Eds), Springer-Verlag, Berlin (2006)
Selected Works:
J. Zheng, J.J. Birktoft, Y. Chen, T. Wang, R. Sha, P.E. Constantinou, S.L. Ginell, C. Mao, & N.C. Seeman, From Molecular to Macroscopic via the Rational Design of a Self-Assembled 3D DNA Crystal, Nature 461, 74-77 (2009).
G. Wu, N. Jonoska & N.C. Seeman, Construction of a DNA Nano-Object Directly Demonstrates Computation, Biosystems 98, 80-84 (2009).
R. Wang, W. Liu & N.C. Seeman, Prototyping Nanorod Control: A DNA Double Helix Sheathed within a DNA 6-Helix Bundle, Chemistry &. Biology 16, 862-867 (2009).
C.H. Spink, L. Ding, Q. Yang, R.D. Sheardy & N.C. Seeman, Thermodynamics of Forming a Parallel Holliday Crossover, Biophysical Journal 97, 528-538 (2009).
C. Liu, N. Jonoska & N.C. Seeman, Reciprocal DNA Nanomechanical Devices Controlled by the Same Set Strands, NanoLetters 9, 2641-2647 (2009).
T. Omabegho, R. Sha & N.C. Seeman, A Bipedal DNA Brownian Motor with Coordinated Legs, Science 324, 67-71 (2009).
H. Gu, J. Chao, S.J. Xiao & N.C. Seeman, Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate, Nature Nanotechnology 4, 245-249, (2009).
R. Dreyfus, M.E. Leunissen, R. Sha, A.V. Tkachenko, N.C. Seeman, D.J. Pine & P.M. Chaikin, A simple quantitative model for the reversible association of DNA coated colloids, Phys. Rev. Lett. 102, Article 048301 (2009).
C. Lin, S. Rinker, X. Wang, Y. Liu, N. C. Seeman & H. Yan, In Vivo Cloning of Artificial DNA Nanostructures, Proc. Nat. Acad. Sci. (USA) 105, 17626-17631 (2008).
Y. Liu, R. Sha, R. Wang, L. Ding , J.W. Canary, & N.C. Seeman, 2',2'-Ligation Demonstrates the Thermal Dependence of DNA-Directed Positional Control, Tetrahedron 64, 9417-8422 (2008).
Y. Liu, A. Kuzuya, R. Sha, J. Guillaume, R. Wang, J.W. Canary & N.C. Seeman, Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini, Journal of the American Chemical Society 130, 10882-10883 (2008).
B. Chakraborty, R. Sha & N.C. Seeman, A DNA-Based Nanomechanical Device with Three Robust States, Proc. Nat. Acad. Sci. (USA) 105, 17245-17249 (2008).
J. Zheng, P.S. Lukeman, W.B. Sherman, C. Micheel, A. P. Alivisatos, P.E. Constantinou & N.C. Seeman, Metallic Nanoparticles Used to Estimate the Structural Integrity of DNA Motifs, Biophysical Journal 95, 3340-3348 (2008).
W. Liu, X. Wang, T. Wang, R. Sha & N.C. Seeman, A PX DNA Triangle Oligomerized Using a Novel Three-Domain Motif, NanoLett 8, 317-322 (2008).
X. Wang & N.C. Seeman, The Assembly and Characterization of 8-Arm and 12-Arm DNA Branched Junctions, J. Am. Chem. Soc. 129, 8169-8176 (2007).
A. Kuzuya, R. Wang, R. Sha & N.C. Seeman, Six-Helix and Eight-Helix DNA Nanotubes Assembled from Half-Tubes, NanoLetters 7, 1757-1763 (2007).
A.V. Garibotti, S. Liao & N.C. Seeman, A Simple DNA-Based Translation System, NanoLetters 7, 480-483 (2007).
H. Zhong & N.C. Seeman, RNA Used to Control a DNA Rotary Machine, NanoLetters 6, 2899-2903 (2006).
B. Ding & N.C. Seeman, Operation of a DNA Robot Arm Inserted Into a 2D DNA Crystalline Substrate, Science 314, 1583-1585 (2006).
G. Wu & N.C. Seeman, A Method of Multiplying with DNA, Natural Computing 5, 427-441, (2006).
J. Zheng, P.E. Constantinou, C. Micheel, A.P. Alivisatos, R.A. Kiehl & N.C. Seeman, 2D Nanoparticle Arrays Show the Organizational Power of Robust DNA Motifs, NanoLetters 6, 1502-1504 (2006).
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